If you’re looking for the best NMN supplement, chances are you’ve heard of its potential anti-aging benefits. Short for nicotinamide mononucleotide, NMN may help boost energy levels, cognition, metabolism, and heart health. But does science support these claims?
This guide takes a look at formulas, pricing, and user feedback to find the best NMN brand you can go for, uncovering some of the best NMN supplements in the market today (starting with GenuinePurity Liposomal NMN). Let’s get started!
Best NMN Supplement: Top Picks for 2025
- GenuinePurity Liposomal NMN – Best NMN Supplement Overall
- Omre NMN + Resveratrol – Highest NMN Dosage per Serving
- Hi-Tech Pharmaceuticals NMN – Most Advanced Delivery System
- Life Extension NAD+ – Best for Rapid Results
- Dr. Emil Nutrition NMN – Best Doctor-Derived Formulation
- Purovitalis Liposomal NMN – Best NMN Supplement for Vegans
How to Choose the Best NMN Supplement for You
There’s nothing wrong with being extra thorough in your search for a suitable NMN supplement. And luckily, we can help you with that. Here are a few things to keep in mind the next time you’re shopping for an NMN supplement.
Ingredient Quality
You should look for two things here: the source of the active ingredient (NMN) and its purity percentage. Enzymatically sourced NMN is usually of better quality than chemically synthesized options.
Pick the NMN brand with a clear purity percentage mentioned on the ingredient label. You need at least 90% purity, as this represents the total amount of NMN in the supplement.
Formula
NMN is available in different forms. So, if you don’t like swallowing huge capsules, you can also get them in sublingual tablets or powders. Some brands also add complementary ingredients for extra benefits. For instance, our #1 pick comes in liposomal capsules to minimize side effects and speed up absorption.
Another example is the second product on our list, Omre, which includes resveratrol to improve the effectiveness of NMN. Your decision will depend mostly on your preference.
Independent Testing
Look for a certificate of analysis (or COA for short) on the official website of the NMN supplement you’re considering. This certificate verifies the purity, potency, and absence of contaminants.
User Feedback
While the product’s official website may show positive NMN supplement reviews only, these may not be enough for you to make an informed decision. Read reviews from trusted product review sites like Trustpilot or check reviews from Amazon and Reddit to get a balanced and detailed perspective of the supplement.
Always remember that individual experiences can vary, though, and consult your doctor when unsure. That said, if you don’t want to do all that hard work, we’ve taken the time and found detailed user feedback and independent NMN supplements reviews for all products below.
Daily Dosage
Are you always on the go or have a busy lifestyle? You may want to choose a supplement that requires a simple dosage, like a few capsules once daily. Anything more than that, and you may find yourself struggling to stick to the dosage guidelines.
Manufacturer Reputation
Prioritize trusted and well-known brands like the ones on our list. These brands are transparent about their manufacturing processes, ingredient sourcing, and third-party testing procedures. If a brand is new or less popular, we recommend researching its background and reputation in the industry.
Detailed Reviews of the Best NMN Supplements
Now, let’s explore the top options you have. We reviewed six of the best NMN supplements on the market, and each has its pros, cons, and a unique offering that makes it stand out from the others. So, read carefully and weigh options as you go, but we are confident you will be able to make an educated decision with this guide.
1. GenuinePurity Liposomal NMN – Best NMN Supplement Overall
Pros
- Over two decades of experience in the field
- 96% pure β-nicotinamide mononucleotide
- Features a certificate of authenticity
- Liposomal capsules maximize absorption
- 97-day money-back guarantee
Cons
- No extra ingredients for added benefits
Overview
GenuinePurity is a Leading Edge Health company that offers the best NMN supplement for those who prioritize simplicity. The supplement includes 250 mg of pure β-nicotinamide mononucleotide (96% purity) in every serving.
It may boost nicotinamide adenine dinucleotide (NAD) levels and promote cellular regeneration to maintain your DNA health even as you age. On top of boosting your energy and strengthening your immunity, NAD may also keep your body’s cells working properly as you grow older [1].
Dosage
- 1 capsule daily
Pricing
- 1 bottle: $69
- 3 bottle: $195
- 6 bottle: $354
User Reviews
If you’re curious to know what customers are saying about GenuinePurity’s best NMN supplement, Reddit reviews are informative.
For example, u/MarkThomasNeo shared on r/NMN that he felt less body aches after heavy workouts after using GenuinePurity’s NMN for 3 to 4 months. On the other hand, he also said it’s too early to see if it can fully combat early aging after many years of partying [2].
What’s more, Leading Edge Health has a great score on Trustpilot. One loyal fan, Duane B., praised the quality and effectiveness of its products, saying he’s a repeat customer. His only gripe? He felt that lowering the high free shipping threshold would make a big difference [3].
>>Check the best deals for GenuinePurity Liposomal NMN
2. Omre NMN + Resveratrol – Highest NMN Dosage per Serving
Pros
- Research-backed dosage
- 500 mg and 99% pure NMN
- Resveratrol to improve the effectiveness
- Zero fillers or artificial additives
- Includes bioperine for maximum absorption
Cons
- Quite short 30-day money-back guarantee
Overview
Omre provides the best NMN supplement with the purest form of NMN (99%) and a high 500 mg dosage. The supplement also includes resveratrol and bioperine to enhance the efficacy of NMN and its absorption, respectively. By raising your NAD levels, it may help improve your cellular energy as well [1].
Dosage
- 2 capsules daily in the morning with food
Pricing
- 1 bottle in a one-time purchase: $59.97
- 1 bottle with a subscription: $53.97
- 3 bottles in a one-time purchase: $152.92
User Reviews
Omre NMN supplement reviews on the official site are a mixed bag. One user, Daniel M, revealed that his doctor recommended it, calling it a total game-changer for all-day energy. He even planned to buy it “forever” despite the relatively high price. Meanwhile, Dmitri had a rougher experience as he received an unsealed item [4].
>>Check the best deals for Omre NMN + Resveratrol
3. Hi-Tech Pharmaceuticals NMN – Most Advanced Delivery System
Pros
- Proprietary Cyclosome delivery system enhances efficacy
- 250 mg of NMN per serving
- It may support metabolism
- It may improve insulin sensitivity
- 60 servings per bottle
Cons
- Just 10% savings on subscriptions regardless of delivery frequency
Overview
Hi-Tech Pharmaceuticals features the best NMN supplement with a cutting-edge Cyclosome delivery system, which combines cyclodextrin and liposomal technologies. This dual encapsulation allows for improved penetration through the intestinal lining and efficient delivery of NMN into the bloodstream for better absorption and bioavailability.
Thanks to its NMN content, it may increase your insulin sensitivity while boosting your metabolism [5].
Dosage
- Just one tablet in the morning with food
- The manufacturer suggests you may take up to 4 tablets daily
Pricing
- 1 bottle (60 servings): $59.95
- 10% off with subscriptions
User Reviews
Redditor u/holdmysugarreported ordered a blind lab test that showed the tablets were underdosed at 214.59 mg instead of the advertised 250 mg [6]. In u/solegenius’ opinion, however, he thought that 86% of label claims weren’t that bad.
For a more rounded perspective, ask friends, family, or fellow enthusiasts of NMN supplements if they’ve tried it. Sometimes, word-of-mouth reveals what the label doesn’t.
>>Check the best deals for Hi-Tech Pharmaceuticals NMN
4. Life Extension NAD+ – Best for Rapid Results
Pros
- Supports healthy cellular metabolism
- Easy-to-swallow capsules
- Vegetarian-friendly
- Unique Niagen blend
Cons
- Slight discounts on subscriptions
Overview
Life Extension takes a different approach to healthy aging by including 300 mg of nicotinamide riboside (NR), marketed as Niagen. One advantage NR has over NMN is that it is a smaller molecule thought to be more easily absorbed by cells [7]. This may translate to faster results from this top NMN supplement alternative with NR.
Dosage
- 1 capsule daily
Pricing
- 1 bottle (30 servings): $40.50
- 10% off with subscriptions
User Reviews
One happy reviewer claimed Life Extension NAD+ gave him a massive energy boost at 65. While another verified user didn’t feel different right away after taking the supplement, he did acknowledge feeling healthier over time [8].
>>Check the best deals for Life Extension NAD+
5. Dr. Emil Nutrition NMN – Best Doctor-Derived Formulation
Pros
- Promotes energy metabolism and cellular health
- It may improve insulin sensitivity and eye function
- 99% purity and high potency ingredients
- Convenient dosage
Cons
- No supporting ingredients
Overview
If you’re looking for the best NMN supplement developed by a doctor, Dr. Emil’s blend includes 400 mg of NMN as SIRTality. This highlights the potential roles of NMN in energy metabolism, insulin sensitivity, and overall health [1]. Furthermore, the supplement is manufactured in a certified GMP facility and is tested by a third party for purity with GRAS status.
Dosage
- 1 capsule daily with around 8 oz of water
Pricing
- 1 bottle (30 servings): $59.95
- 1 bottle with a monthly subscription: $44.96
User Reviews
Dr. Emil Nutrition NMN is winning over customers like Marsha Gilliam, though with a few reservations. After two weeks of using the supplement, she noticed benefits like an energy boost and appetite control. However, she felt the price tag was steep [9].
>>Check the best deals for Dr. Emil Nutrition NMN
6. Purovitalis Liposomal NMN – Best NMN Supplement for Vegans
Pros
- Patented liposomal technology improves absorption
- Supports cellular energy
- Vegan-friendly
- Easily digestible capsules
Cons
- Short 30 money-back guarantee
Overview
Purovitalis Liposomal NMN is manufactured in Europe with patented liposomal technology, which the company claims doubles the absorption rate. As the best NMN supplement for vegans, it comes in easily digestible HPMC capsules and includes lecithin for improved efficacy. To amp up your energy and metabolism, it aims to raise your NAD levels [1].
Dosage
- 2 capsules daily with breakfast
Pricing
- 1 bottle (30 servings): Buy one time for $52.99 or subscribe and pay $47.99
User Reviews
Purovitalis Liposomal NMN has its fair share of fans but also a few frustrated customers. On Trustpilot, Tammy raved about the supplement’s life-changing effects on her body and mind, plus stellar customer service in her NMN supplement review [10]. On the other hand, Andrea didn’t like the unexpected customs fees for U.S. buyers [11].
>>Check the best deals for Purovitalis Liposomal NMN
What Are NMN Supplements?
As mentioned earlier, NMN is short for nicotinamide mononucleotide. Supplements that feature it usually include an optimized version of the molecule to make it work better. NMN is a precursor to nicotinamide adenine dinucleotide, commonly known as NAD or NAD+. This means the former undergoes a chemical reaction in the body to become the latter.
NAD is linked to potential benefits like improved heart health, cognition, metabolism, and even slowing down certain aspects of aging [12] [1]. However, it naturally declines with age, which is one of the main reasons NMN supplements are gaining popularity.
Do NMN Supplements Work?
Research, mostly in animals, suggests NMN can boost NAD levels, a coenzyme crucial for cellular energy production and repair [13]. This increase in NAD has been linked to potential benefits like improved metabolism, cardiovascular health, and cognitive function [1] [12].
However, human studies are limited, and long-term effects remain unknown. Some clinical trials indicate potential benefits for insulin sensitivity and peak performance for NMN users [5]. Yet, more research is needed to confirm these findings and establish optimal dosages.
Forms of NMN
NMN is not easily digested in your system. So, various forms like liposomal or sublingual exist to help deliver more of the compound directly to your bloodstream. The common forms of NMN include:
Liposomal
Liposomes are tiny fat bubbles that protect an active ingredient (NMN in this case) from degradation. In short, they help ensure that NMN reaches its target tissues intact, optimizing its potential health benefits.
Non-Liposomal
This is the standard form of most generic NMN supplements, usually as capsules or powders. The best NMN powder or capsules are generally more affordable but might have a lower absorption rate than liposomal NMN.
Sublingual
Taken by placing it under the tongue, this form allows NMN to be absorbed directly into the bloodstream. The sublingual form can bypass the digestive system, potentially leading to faster and more efficient absorption.
Common Ingredients in NMN Supplements
While NMN is the star ingredient, you’ll often find other compounds in NMN supplements to enhance its effects or provide additional benefits. Let’s start with the star of the show and then explore some common additions:
NMN
NMN is the critical ingredient in the synthesis of nicotinamide adenine dinucleotide. Increasing cellular NAD+ has been found to improve keratinocyte regenerative capacity, activate mitophagy, and enhance mitochondrial function [14].
In simple terms, NMN can help your cells’ power plants work better, recycle old ones, and keep your skin healthy. It’s just like giving your body a boost of energy and vitality at a cellular level.
Trans-Resveratrol
Trans-resveratrol works with NMN to increase NAD levels. It can also activate sirtuins on its own. These proteins play a role in various cellular processes related to stress resistance, aging, and metabolism [15].
Phosphatidylcholine
On its own, phosphatidylcholine supports brain health and cell membrane function, which may complement NMN’s potential anti-aging effects [16]. When combined, it helps improve NMN’s absorption and effectiveness in the digestive system.
Pterostilbene
As a resveratrol derivative, pterostilbene activates sirtuins, proteins linked to longevity and cellular health. This may help maximize NMN’s utilization for cellular energy production and health.
Green Tea Extract
Both green tea extract and NMN have been individually studied for their potential benefits in cellular health, antioxidant support, and metabolic function [17].
Combining these two ingredients may offer a more comprehensive approach to supporting longevity and healthy aging. They can work together to combat oxidative stress, promote cellular energy, and protect against age-related diseases.
Vitamin D
Some research suggests vitamin D might play a role in NAD+ metabolism, potentially further supporting NMN’s action in the body [18].
Apigenin
By inhibiting an enzyme called CD38, which breaks down nicotinamide adenine dinucleotide in the body, apigenin slows down the degradation of NAD+ [19]. The combo will play out like this: NMN supplies the building blocks for nicotinamide adenine dinucleotide. On the other hand, apigenin protects the NAD from being depleted, leading to a more significant increase.
Ergothioneine
Essentially, ergothioneine helps create a more supportive environment for NMN to work effectively. It does so by reducing oxidative stress and promoting overall cellular health [20].
>>Check the best deals for GenuinePurity Liposomal NMN here
Benefits of NMN Supplements
Here are some of the main reasons NMN supplements are gaining popularity. So, what is NMN good for? Here’s a breakdown of the potential benefits. Just keep in mind that research is still ongoing:
Anti-Aging Effects
NMN offers this benefit in two ways. First, it boosts NAD, a coenzyme crucial for cellular energy production and repair. As nicotinamide adenine dinucleotide levels decline with age, supplementing with NMN may help slow down some aspects of aging [21].
The second pathway is indirect sirtuin activation. Excess NAD is vital for sirtuins, proteins linked to longevity and cellular health [22]. By boosting NAD levels, NMN might indirectly activate sirtuins, potentially promoting healthy aging.
Cardiovascular Support
What is NMN supplementation’s effect on heart health? It enhances blood flow and protects blood vessels from damage, reducing the risk of heart disease. NMN’s antioxidant effects can also protect the heart from damage caused by free radicals [23].
Metabolic Benefits
Like the best metabolism booster supplements, some studies suggest NMN may help with weight loss or prevent age-related weight gain. This could be because it improves the way the body uses insulin and manages blood sugar levels [24]. This mechanism could also potentially benefit those with type 2 diabetes or insulin resistance.
Enhanced Cognitive Function
One study showed that NMN alone or combined with melatonin may reverse learning deficits and age-related diseases in the brains of older animals [25].
For those who are interested in learning how to increase attention span and improve cognitive health, it’s good to note that while human studies still need to be more conclusive, this finding suggests that NMN may hold promise for supporting cognitive function and potentially mitigating the risk or progression of Alzheimer’s disease.
Improved Energy Production
We already know that NMN boosts NAD+, which is essential for mitochondria, the powerhouses of cells. This can lead to increased energy levels [1].
Improved Muscle Function
In addition, we found a paper suggesting that NMN may improve muscle function and endurance, particularly in older adults [26].
Reduced Inflammation
NMN’s antioxidant and NAD-boosting effects may help relieve inflammation throughout the body. One research paper showed that NMN supplementation decreased inflammation markers like Cyclooxygenase 2 and Prostaglandin E2 [27]. These results suggest that NMN supplementation could be a practical approach to chronic inflammation treatment.
>>Check the best deals for GenuinePurity Liposomal NMN here
Potential Side Effects of NMN Supplements
Most of the top NMN supplements we reviewed are generally considered safe when used as directed. However, some people may experience mild side effects like:
- Gastrointestinal issues
- Flushing or redness
- Headache or dizziness
- Sleep disturbances
- Elevated heart rate
It’s important to note that these side effects are usually mild and temporary. If you experience any persistent or bothersome side effects, stop taking the supplement ASAP and consult your doctor.
Who Are NMN Supplements Good For?
Is NMN good for you? NMN supplements could be a great choice for adults interested in promoting healthy aging and overall wellness. They may be particularly helpful as metabolism boosters for older folks experiencing age-related declines in energy levels, cognitive function, or metabolic health.
Those with concerns about cardiovascular health or persons seeking to support their body’s natural repair processes might also find NMN supplementation beneficial.
Who Should Avoid NMN?
People who fall under any of the categories below should exercise caution when taking NMN supplements or avoid them altogether:
- Pregnant or breastfeeding women: There’s insufficient research on NMN’s safety during pregnancy and breastfeeding, but caution should be taken here.
- Individuals with existing health conditions: Those with liver or kidney disease, cancer, or other serious health issues should consult their doctor before taking NMN.
- People taking certain medications: NMN might interact with some medications, such as blood thinners or chemotherapy drugs.
- Those with allergies or sensitivities: Some NMN supplements contain additional ingredients that could trigger allergies.
FAQs About NMN Supplements
Still have questions? You’re not alone! Here are some common queries about the best NMN supplements that might help you find the perfect fit for you.
What Is the Most Reputable NMN Supplement?
Based on our NMN supplement reviews, GenuinePurity Liposomal NMN takes the lead. But getting a direct answer to “What is the best NMN supplement?” is tricky. After all, the other brands we reviewed also received high praise and demonstrated a commitment to quality. Ultimately, choosing “the one” among the options on our list will boil down to your preference.
What Brand of NMN Does David Sinclair Take?
David Sinclair doesn’t publicly endorse or reveal specific brands of NMN that he uses. He only emphasizes the importance of choosing high-quality NMN supplements with rigorous third-party testing to ensure purity and effectiveness.
What Is the Best Form of NMN to Take?
The best NMN form to take is debatable, but liposomal NMN is a popular choice among most users. It encapsulates the NMN molecule in tiny fat bubbles, potentially leading to better absorption and protection from degradation in the digestive system.
When Is the Best Time to Take NMN Supplement?
Taking NMN in the morning, ideally on an empty stomach, is often recommended. This allows for quicker absorption and may coincide with your body’s natural NAD+ production cycles. However, some experts suggest splitting the dose – with one in the morning and another in the afternoon – to maintain consistent NAD+ levels throughout the day.
What Happens When You Stop Taking NMN?
NMN boosts NAD, so your NAD levels will gradually return to their previous baseline. This could mean a gradual decline in energy levels, slower metabolism, and potentially decreased cognitive function or cardiovascular health improvements.
Is NMN Really Worth It?
How rewarding NMN is depends on your goals and expectations. While research on its efficacy is promising, human clinical trials are still ongoing. If you’re on the fence about getting it, a few things can help you pick a side. Consider your budget, health goals, and willingness to incorporate lifestyle changes alongside supplementation.
Best NMN Supplement: Final Verdict
While NMN has the potential to offer a wide range of benefits, human studies are still ongoing. Choosing the best NMN supplement from a trusted brand is thus all the more important. GenuinePurity Liposomal NMN is our #1 pick because it combines the benefits of MNM with liposomal capsules for maximum efficacy and absorption.
However, NMN supplement reviews show other options are well worth exploring, so our overview makes for a great starting point for your research. Having read our NMN supplement reviews, it’s time for you to choose one that fits your needs and all the boxes!
>>Learn more about GenuinePurity Liposomal NMN
References
- Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. (2020). NAD+ metabolism and its roles in cellular processes during aging. Nature Reviews Molecular Cell Biology, 22(2), 119–141. https://doi.org/10.1038/s41580-020-00313-x
- Reddit – Dive into anything. (2024). Reddit.com. https://www.reddit.com/r/NMN/comments/19590ce/genuinepurity_liposomal_nmn/
- “Duane B. Gave Leading Edge Health 5 Stars. Check out the Full Review.” Trustpilot, https://www.trustpilot.com/reviews/672ba26a3c80e4f1c035cbe5.
- “NMN + RESVERATROL.” Omre, https://omre.co/products/nmn-resveratrol.
- Yoshino, M., Yoshino, J., Kayser, B. D., Patti, G., Franczyk, M. P., Mills, K. F., Sindelar, M., Pietka, T., Patterson, B. W., Imai, S.-I., & Klein, S. (2021). Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science, 372(6547). https://doi.org/10.1126/science.abe9985
- holdmysugar. “Hi Tech Pharmaceuticals NMN 3rd Party Test Results :(.” Reddit, https://www.reddit.com/. Accessed 19 Nov. 2024.
- Mehmel, M., Jovanović, N., & Spitz, U. (2020). Nicotinamide Riboside—The Current State of Research and Therapeutic Uses. Nutrients, 12(6), 1616. https://doi.org/10.3390/nu12061616
- “NAD+ Cell RegeneratorTM, 100 Mg, 30 Vegetarian Capsules – Life Extension.” Lifeextension.Com, https://www.lifeextension.com/vitamins-supplements/item01904/nad-cell-regenerator?
- “NMN – 400mg.” Dr Emil Nutrition, https://dremilnutrition.com/products/nmn.
- “Tammy Mason Gave Purovitalis 5 Stars. Check out the Full Review.” Trustpilot, https://www.trustpilot.com/reviews/672d2f36b5ed7e50567f2a46.
- “Andrea Kokedhima Gave Purovitalis 2 Stars. Check out the Full Review.” Trustpilot, https://www.trustpilot.com/reviews/64aac71b706f837cb10c8480.
- Lin, Q., Zuo, W., Liu, Y., Wu, K., & Liu, Q. (2021). NAD+ and cardiovascular diseases. Clinica Chimica Acta, 515, 104–110. https://doi.org/10.1016/j.cca.2021.01.012
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- Conlon, Nichola J. “The Role of NAD+ in Regenerative Medicine.” Plastic and Reconstructive Surgery, vol. 150, no. 4 Suppl, 2022, pp. 41S-48S, doi:10.1097/PRS.0000000000009673.
- Mohar, Dilbahar S., and Shaista Malik. “The Sirtuin System: The Holy Grail of Resveratrol?” Journal of Clinical & Experimental Cardiology, vol. 3, no. 11, 2012, p. 216, doi:10.4172/2155-9880.1000216.
- Chung, S. Y., et al. “Administration of Phosphatidylcholine Increases Brain Acetylcholine Concentration and Improves Memory in Mice with Dementia.” The Journal of Nutrition, vol. 125, no. 6, 1995, pp. 1484–1489, doi:10.1093/jn/125.6.1484.
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